Covid has the ability to reactivate latent bacterial infections. According to research, the SARS-CoV-2 virus that causes Covid-19 may have the potential to reawaken dormant tuberculosis (TB). This is concerning news for nations like India, where an estimated 40% of the population has dormant or latent TB.
Researchers from the Indian Institute of Technology, Guwahati. And the University of Massachusetts demonstrated that infection with a particular coronavirus strain reactivated latent Mycobacterium tuberculosis (MTB) in mice.
The findings, published in The American Journal of Pathology, may open the door for new anti-TB vaccinations and help avert a worldwide TB pandemic.
“TB reactivation in an undifferentiated organism interceded tuberculosis torpidity creature model after MHV-1 Covid contamination shows. That the SARS-CoV-2 infection may stir dormant bacterial illnesses in the long haul, post-pandemic. This is a significant finding in light of the current coronavirus pandemic. Which may result in an increase in active tuberculosis cases among many individuals in India and other developing countries with dormant tuberculosis. “Bikul Das, from the Department of Stem Cell and Infectious Diseases at IIT-KaviKrishna Guwahati’s Laboratory, explained the lead investigator.
“It is basic to explore the association of Covid-19 with inert tuberculosis reactivation to turn away an overall TB pestilence,” Das said.
The researchers examined the coronavirus strain murine hepatitis virus-1 (MHV-1) infection in the lung of a mouse model (dMtb) of MTB dormancy mediated by mesenchymal stem cells (MSCs). By the third week of viral infection. This resulted in a 20-fold reduction in viral loads compared to dMtb-free control mice. And a six-fold increase in altruistic stem cells (ASCs), thus boosting defense.
Tuberculosis was reactivated in dMtb mice, indicating that latent tuberculosis bacteria hijack these ASCs and multiply in the lung. Causing pulmonary tuberculosis. The results indicate that these ASCs are transitory (they grow for two weeks and then die). And show antiviral activity against MHV-1 through the secretion of soluble components.
“It is basic to see how the bodyguard itself against this ailment to make a more powerful immunization or potentially treatment. As a result, we hypothesized that, like bacteria. Therefore, Adult stem cells may show an altruistic defense mechanism to defend their niche from external threats “As Das said.